Fenfluramine--induced irreversible pulmonary hypertension.
نویسندگان
چکیده
منابع مشابه
Pulmonary hypertension and fenfluramine.
Pulmonary hypertension developed in two women who had been taking fenfluramine for over eight months for weight reduction. On withdrawing the drug symptoms and electrocardiographic evidence of pulmonary hypertension disappeared in both cases. In one patient, however, the evidence recurred after rechallenge with fenfluramine. These findings are strong evidence that fenfluramine may cause pulmona...
متن کاملPulmonary hypertension and fenfluramine.
Pulmonary hypertension developed in two women who had been taking fenfluramine for over eight months for weight reduction. On withdrawing the drug symptoms and electrocardiographic evidence of pulmonary hypertension disappeared in both cases. In one patient, however, the evidence recurred after rechallenge with fenfluramine.These findings are strong evidence that fenfluramine may cause pulmonar...
متن کاملPrimary pulmonary hypertension and fenfluramine use.
Not all the risk factors for primary pulmonary hypertension (PPH) are known. Appetite suppressants, including fenfluramine derivatives, are strongly suspected aetiological agents. In a 5 year retrospective study fenfluramine use was evaluated among patients referred to a medical centre specialising in the management of PPH. Fifteen (20%) of 73 patients with PPH had used fenfluramine: all of the...
متن کاملBMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives.
This study investigated whether patients developing pulmonary arterial hypertension (PAH) after exposure to the appetite suppressants fenfluramine and dexfenfluramine have mutations in the bone morphogenetic protein receptor 2 (BMPR2) gene, as reported in primary pulmonary hypertension. BMPR2 was examined for mutations in 33 unrelated patients with sporadic PAH, and in two sisters with PAH, all...
متن کاملIrreversible pulmonary hypertension after correction of tetralogy of Fallot.
A case of tetralogy of Fallot in which irreversible pulmonary hypertension d e veloped in the postoperative period is presented. A recent cardiac catheterization has shown this to be caused by reopening of the ventricular septum and complete relief of infundibular pulmonic stenosis. The patient's hemodynamics are now those of a ventricular septal defect with reversal of shunting. The need for c...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1991
ISSN: 0032-5473
DOI: 10.1136/pgmj.67.790.776-a